Understanding diversity is important in our inclusive society to hedge against ignorance and accommodate plural perspectives. Diversity nowadays can be observed in online social spaces. People from different backgrounds (e.g. gender, age, culture, expertise) are interacting every day around online digital objects (e.g. videos, images and web articles) leaving their social content in different format, commonly as textual comments and profiles. The social clouds around digital objects (i.e. user comments, user profiles and other metadata of digital objects) offer rich source of information about the users and their perspectives on different domains. Although, researchers from disparate disciplines have been working on understanding and measuring diversity from different perspectives, little has been done to automatically measure diversity in social clouds. This is the main objective of this research. This research proposes a semantic driven computational model to systematically represent and automatically measure diversity in a social cloud. Definitions from a prominent diversity framework and Semantic Web techniques underpin the proposed model. Diversity is measured based on four diversity indices - variety, balance, coverage and (within and across) disparity with regards to two perspectives – (a) domain, which is captured in user comments and represented by domain ontologies, and (b) user, which is captured in profiles of users who made the comments and represented by a proposed User Diversity Ontology. The proposed model is operationalised resulting in a Semantic Driven Diversity Analytics Tool (SeDDAT), which is responsible for diversity profiling based on the diversity indices. The proposed approach of applying the model is illustrated on social clouds from two social spaces - open (YouTube) and closed (Active Video Watching (AVW-Space)). The open social cloud shows the applicability of the model to generate diversity profiles of a large pool of videos (600) with thousands of users and comments. Closed social clouds of two user groups around same set of videos illustrate transferability and further utility of the model. A list of possible diversity patterns within social clouds is provided, which in turn deepen the understanding of diversity and open doors for further utilities of the diversity profiles. The proposed model is applicable in similar scenarios, such as in the social clouds around MOOCs and news articles.

Colour image watermarking has become one of the most important algorithms for copyright protection. The following paper will present an innovative scheme for watermarking blind colour images using the discrete wavelet transform (DWT), fast Walsh Hadamard transform (FWHT) and the Hessenberg decomposition as its basis. First, two-level DWT followed by FWHT are used to decompose the host image’s red channel. Next, the FWHT coefficients are split into 4× 4 non-overlapping blocks. Then, each selected block is decomposed using Hessenberg decomposition, where the first row, first column element of the upper Hessenberg matrix H is quantified to embed the watermark information. Peak signalto-noise ratio, normalized cross-correlation and structural similarity index measure are used to evaluate the feasibility and the robustness. The experimental results have demonstrated that the proposed watermarking scheme is highly invisible with PSNR> 40 dB, for several watermarked colour images, with a capacity of 4096 bits and execution time of 0.7415 s. The proposed watermarking scheme is also highly resistant to both common image processing and geometrical attacks such as filtering, JPEG2000, noise adding, cropping, scaling, blurring and sharpening, and others

Modelling diversity is especially valuable in soft skills learning, where contextual awareness and understanding of different perspectives are crucial. This paper presents an application of a diversity analytics pipeline to generate domain diversity profiles for learners as captured in their comments while watching videos for learning a soft skill. The datasets for analysis were collected from a series of studies on learning presentation skills with Active Video Watching system (AVW-Space). Two user studies (with 37 postgraduates and 140 undergraduates, respectively) were compared. The learners’ diversity and personal profiles are used to further understand and highlight any notable patterns about their domain coverage on presentation skills.

Diversity has been the subject of study in various disciplines from biology to social science and computing. Respecting and utilising the diversity of the population is increasingly important to broadening knowledge. This paper describes a pipeline for diversity profiling of a pool of text in order to understand its coverage of an underpinning domain. The application is illustrated by using a domain ontology on presentation skills in a case study with 38 postgraduates who made comments while learning pitch presentations with the Active Video Watching system (AVW-Space). The outcome shows different patterns of coverage on the domain by the comments in each of the eight videos.

Structural changes affecting cardiomyocyte function may contribute to the pathophysiological

remodeling underlying cardiac function impairment. Recent reports have shown that

endogenous nitric oxide (NO) plays an important role in this process. In order to examine the role

of NO in cardiomyocyte remodeling, male rats were acclimated to room temperature (22± 1
C) or

cold (4 ± 1
C) and treated with 2.25% L-arginine
HCl or 0.01% L-NAME (Nx-nitro-L-arginine

methyl ester)
HCl for 45 days. Untreated groups served as controls. Right heart ventricles were routinely

prepared for light microscopic examination. Stereological estimations of volume densities of

cardiomyocytes, surrounding blood vessels and connective tissue, as well as the morphometric measurements

of cardiomyocyte diameters were performed. Tissue sections were also analyzed for

structural alterations. We observed that both L-arginine and L-NAME supplementation induced

cardiomyocyte hypertrophy, regardless of ambient temperature. However, cardiomyocyte hypertrophy

was associated with fibrosis and extra collagen deposition only in the L-NAME treated group.

Taken together, our results suggest that NO has a modulatory role in right heart ventricle remodeling

by coordinating hypertrophy of cardiomyocytes and fibrous tissue preventing cardiac fibrosis.

Abstract—Early detection of malignant melanoma skin cancer is crucial for treating the disease and saving lives. Many computerized techniques have been reported in the literature to diagnose and classify the disease with satisfactory skin cancer detection performance. However, reducing the false detection rate is still challenging and preoccupying because false positives trigger the alarm and require intervention by an expert pathologist for further examination and screening. In this paper, an automatic skin cancer diagno- sis system that combines different textural and color features is proposed. New textural and color features are used in a bag-of-features approach for efficient and accurate detection. We particularly claim that the Histogram of Gradients (HG) and the Histogram of Lines (HL) are more suitable for the analysis and clas- sification of dermoscopic and standard skin images than the conventional Histogram of Oriented Gradient (HOG) and the Histogram of Oriented Lines (HOL), respectively. The HG and HL are bagged separately us- ing a codebook for each and then combined with other bagged color vector angles and Zernike moments to exploit the color information. The overall system has been assessed through intensive experiments using different classifiers on a dermoscopic image dataset and another standard dataset. Experimental results have shown the superiority of the proposed system over state-of-the-art techniques.

Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various Leishmania species possess similar pyrimidine transporters capable of drug uptake. Here, we report a comprehensive characterization of pyrimidine transport in L. major and L. mexicana. In both species, two transporters for uridine/adenosine were detected, one of which also transported uracil and the antimetabolites 5-fluoruracil (5-FU) and 5F,2'deoxyuridine (5F,2'dUrd), and was designated uridine-uracil transporter 1 (UUT1); the other transporter mediated uptake of adenosine, uridine, 5F,2'dUrd and thymidine and was designated Nucleoside Transporter 1 (NT1). To verify the reported L. donovani model of two NT1-like genes encoding uridine/adenosine transporters, and an NT2 gene encoding an inosine transporter, we cloned the corresponding L. major and L. mexicana genes, expressing each in T. brucei. Consistent with the L. donovani reports, the NT1-like genes of either species mediated the adenosine-sensitive uptake of [3H]-uridine but not of [3H]-inosine. Conversely, the NT2-like genes mediated uptake of [3H]-inosine but not [3H]-uridine. Among pyrimidine antimetabolites tested, 5-FU and 5F,2'dUrd were the most effective antileishmanials; resistance to both analogs was induced in L. major and L. mexicana. In each case it was found that the resistant cells had lost the transport capacity for the inducing drug. Metabolomics analysis found that the mechanism of action of 5-FU and 5F-2'dUrd was similar in both Leishmania species, with major changes in deoxynucleotide metabolism. We conclude that the pyrimidine salvage system is highly conserved in Leishmania species - essential information for the development of pyrimidine-based chemotherapy.

The current paper proposes a novel scheme for non-blind watermarking of images, making use of discrete wavelet transform (DWT), discrete time Fourier transform (DTFT), as well as singular value decomposition, or SVD. During the process of embedding, 1-level DWT is used to decompose the host image into its various frequency sub-bands. After this, the high-frequency sub band receives an application of DTFT. This is followed then by SVD, after which the watermark becomes embedded into the now-transformed host image's singular matrix. Then, the inverses of 1-level DWT, DTFT and SVD are applied in order to obtain a watermarked final image. This paper evaluates the performance of the proposed method of watermarking against a number of attacks, including sharpening, salt and pepper noise, AWGN, gamma correction, histogram equalisation, flipping and cropping. Results obtained during experiments have found that the scheme as proposed does provide high levels of robustness and imperceptibility against various signal processing attacks.